NMDAR expression in the cochlear nucleus and hearing damage in neonatal rats with hyperbilirubinemia / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
;
(12): 201-204, 2010.
Artigo
em Chinês
| WPRIM
| ID: wpr-270388
ABSTRACT
<p><b>OBJECTIVE</b>To study the role of N-methyl-D-aspartate-receptor (NMDAR) expression in the development of hearing damage in neonatal rats with hyperbilirubinemia.</p><p><b>METHODS</b>Sixty seven-day-old Sprague-Dawley rats were randomly injected with bilirubin of 100 microg/g (low-dose treatment group) or 200 microg/g (high-dose treatment group) or normal saline (control group). Auditory brainstem response (ABR) was examined. The concentrations of bilirubin in blood and brain were measured. NMDAR expression in the cochlear nucleus slices was examined by immunohistochemistry assay.</p><p><b>RESULTS</b>ABR reflecting threshold obviously increased, and I, II and III wave latency as well as I-II, II-III and I-III interval were more prolonged in the two bilirubin treatment groups when compared with the control group. The NMDAR expression in the cochlear nucleuse in the two bilirubin treatment groups was obviously lower than that in the control group. The NMDAR expression in the cochlear nucleuse was negatively correlated with the brain bilirubin content and the ABR reflecting threshold in the two bilirubin treatment groups.</p><p><b>CONCLUSIONS</b>An increased NMDAR activity may play an important role in hearing damage following hyperbilirubinemia.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Bilirrubina
/
Imuno-Histoquímica
/
Química
/
Potenciais Evocados Auditivos do Tronco Encefálico
/
Ratos Sprague-Dawley
/
Receptores de N-Metil-D-Aspartato
/
Núcleo Coclear
/
Transtornos da Audição
/
Hiperbilirrubinemia
/
Animais Recém-Nascidos
Limite:
Animais
Idioma:
Chinês
Revista:
Chinese Journal of Contemporary Pediatrics
Ano de publicação:
2010
Tipo de documento:
Artigo
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