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Protective effects of curcumin on neonatal rats with necrotizing enterocolitis / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics ; (12): 132-136, 2010.
Artigo em Chinês | WPRIM | ID: wpr-270411
ABSTRACT
<p><b>OBJECTIVE</b>This study examined the effects of curcumin on intestinal histopathological changes, cyclooxygenase-2 (COX-2) expression, and tumor necrosis factor-alpha (TNF-alpha) and interleukin-10 (IL-10) concentrations in neonatal rats with necrotizing enterocolitis (NEC), in order to investigate the effects of curcumin against NEC.</p><p><b>METHODS</b>Forty neonatal rats were randomly divided into four groups (n=10 each) normal control, solvent control, NEC model, and curcumin intervention. The general situations of rats were observed for 3 consecutive days, and the rats were then sacrificed on the 4th day. Intestinal tissues were obtained for examining the histopathological changes, COX-2 expression, and TNF-alpha and IL-10 concentrations.</p><p><b>RESULTS</b>Curcumin treatment ameliorated the general situations and histopathological signs in rats with NEC. TNF-alpha and IL-10 concentrations in the NEC model and the curcumin intervention groups increased significantly compared with those in the normal and solvent control groups (p<0.05). The concentration of TNF-alpha decreased (p<0.05), while the concentration of IL-10 increased significantly in the curcumin intervention group in comparison with the NEC model group (p<0.05). Immunohistochemistry results indicated that the positive expression of COX-2 in the curcumin intervention group was significantly lower than that in the NEC model group.</p><p><b>CONCLUSIONS</b>Curcumin has protective effects against NEC in neonatal rats, possibly through inhibiting COX-2 expression, reducing TNF-alpha content, and increasing IL-10 content.</p>
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Patologia / Fisiologia / Peso Corporal / NF-kappa B / Fator de Necrose Tumoral alfa / Interleucina-10 / Ratos Sprague-Dawley / Enterocolite Necrosante / Curcumina / Usos Terapêuticos Tipo de estudo: Estudo prognóstico Limite: Animais Idioma: Chinês Revista: Chinese Journal of Contemporary Pediatrics Ano de publicação: 2010 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Patologia / Fisiologia / Peso Corporal / NF-kappa B / Fator de Necrose Tumoral alfa / Interleucina-10 / Ratos Sprague-Dawley / Enterocolite Necrosante / Curcumina / Usos Terapêuticos Tipo de estudo: Estudo prognóstico Limite: Animais Idioma: Chinês Revista: Chinese Journal of Contemporary Pediatrics Ano de publicação: 2010 Tipo de documento: Artigo