Concentrations of granulocyte colony-stimulating factor in children with moyamoya disease / 中国当代儿科杂志

ABSTRACT

<p><b>OBJECTIVE</b>To explore the roles of granulocyte colony-stimulating factor in the pathogenesis of moyamoya disease.</p><p><b>METHODS</b>Serum G-CSF concentrations were measured using enzyme linked immunosorbent assay (ELISA) in 20 children with moyamoya disease and 20 healthy children.</p><p><b>RESULTS</b>Serum G-CSF concentration (35.7+/-10.3 pg/mL) in children with moyamoya disease was significantly higher than that in healthy controls (23.5+/-3.8 pg/mL) (p<0.01).</p><p><b>CONCLUSIONS</b>The elevated serum G-CSF concentration in children with moyamoya disease suggests that G-CSF may play an important role in the pathogenesis of moyamoya disease.</p>