In vitro Antagonism between Cefotaxime and Anti-Rickettsial Antibiotics against Orientia tsutsugamushi / 감염과화학요법
Infection and Chemotherapy
;
: 189-193, 2014.
Artigo
em Inglês
| WPRIM
| ID: wpr-27053
ABSTRACT
We have investigated the in vitro antimicrobial effects of antibiotic combinations against Orientia tsutsugamushi, the causative agent of scrub typhus. ECV304 cells were infected with the Boryong strain of O. tsutsugamushi and incubated in a medium containing doxycycline (4 microg/mL), azithromycin (0.5 microg/mL), rifampin (4 microg/mL), ciprofloxacin (25 microg/mL), gentamicin (5 microg/mL), cefotaxime (2 microg/mL), or combinations of these agents for 7 days, after which immunofluorescent staining for O. tsutsugamushi was performed. The percentages of infective foci in cultures containing antibiotics compared to those in cultures without antibiotics were 6.2% for doxycycline, 9.6% for azithromycin, 8.8% for rifampin, 96.6% for cefotaxime, 29.7% for doxycycline plus cefotaxime, 23.6% for azithromycin plus cefotaxime, and 41.4% for rifampin plus cefotaxime. These findings show an in vitro antagonism between anti-rickettsial agents and cefotaxime against O. tsutsugamushi. These results suggest that the efficacy of antibiotic combinations involving cefotaxime for the treatment of patients with scrub typhus, particularly those with severe pneumonia, needs to be investigated.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Pneumonia
/
Orientia tsutsugamushi
/
Rifampina
/
Tifo por Ácaros
/
Gentamicinas
/
Ciprofloxacina
/
Cefotaxima
/
Doxiciclina
/
Azitromicina
/
Antagonismo de Drogas
Limite:
Humanos
Idioma:
Inglês
Revista:
Infection and Chemotherapy
Ano de publicação:
2014
Tipo de documento:
Artigo
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