Bioinformatics analysis raises candidate genes in blood for early screening of Parkinson's disease / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences
;
(12): 462-465, 2014.
Artigo
em Inglês
| WPRIM
| ID: wpr-270580
ABSTRACT
Parkinson's disease (PD) is a typical degenerative disease, which is characterized by the most obvious symptoms of movement dysfunction, including shaking, rigidity, slowness of movement and difficulty in walking and gait. This disease can not be clearly identified through laboratory tests at present, thus application of high-throughput technique in studying the expression profiles of PD helps to find the genetic markers for its early diagnosis. Studies on expression profiles of neurodegenerative diseases have revealed the novel genes and pathways involved in the progress of illness. In this study, the expression profiles of PD in blood were compared, showing that 181 differentially expressed genes (DEG) exhibit a similar expression trend both in patients and in normal controls. These genes are enriched significantly in some biological processes, including development, response to drugs, and DNA-dependent regulation of transcription, etc, highlighting that the genetic markers can be used in early diagnosis of PD.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Doença de Parkinson
/
Sangue
/
Biomarcadores
/
Marcadores Genéticos
/
Estudos de Casos e Controles
/
Programas de Rastreamento
/
Biologia Computacional
/
Perfilação da Expressão Gênica
/
Diagnóstico Precoce
/
Diagnóstico
Tipo de estudo:
Estudo diagnóstico
/
Estudo observacional
/
Estudo de rastreamento
Limite:
Humanos
Idioma:
Inglês
Revista:
Biomedical and Environmental Sciences
Ano de publicação:
2014
Tipo de documento:
Artigo
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