Di-(n-butyl)-phthalate-induced oxidative stress and depression-like behavior in mice with or without ovalbumin immunization / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences
;
(12): 268-280, 2014.
Artigo
em Inglês
| WPRIM
| ID: wpr-270605
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the relationship between atopic allergy and depression and the role of DBP in the development of depression.</p><p><b>METHODS</b>BALB/c mice were randomly divided into eight groups saline; ovalbumin (OVA)-immunized; saline+DBP (0.45 mg/kg•d); saline+DBP (45 mg/kg•d); DBP (0.45 mg/kg•d) OVA-immunized; DBP (45 mg/kg•d) OVA-immunized; saline+hydrocortisone (30 mg/kg•d); and hydrocortisone (30 mg/kg•d)-exposed OVA-immunized. Behavior (e.g. open-field, tail suspension, and forced swimming tests), viscera coefficients (brain and spleen), oxidative damage [e.g. reactive oxygen species (ROS), malondialdehyde (MDA), and glutathione (GSH)], as well as levels of IgE and IL-4, were then analyzed.</p><p><b>RESULTS</b>In the saline and OVA groups, the degree of depression symptoms in mice increased with increasing DBP concentration. Additionally, the OVA-immunity groups were associated with more serious depressive behavior compared with the same exposure concentration in the saline group. Oxidative damage was associated with a dose-dependent increase in DBP in the different groups. IL-4 and IgE levels were associated with low-dose DBP stimulation, which changed to high-dose inhibition with increasing DBP exposure, possibly due to spleen injury seen at high DBP concentrations.</p><p><b>CONCLUSION</b>Development of an atopic allergy has the potential to increase the risk of depression in mice, and it seems that DBP helps OVA to exert its effect in our present model. Moreover, the results of our study implicate a certain connection between brain oxidative stress and depression, which deserves a further exploration.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Comportamento Animal
/
Sangue
/
Peso Corporal
/
Imunoglobulina E
/
Hidrocortisona
/
Ovalbumina
/
Interleucina-4
/
Imunização
/
Estresse Oxidativo
/
Depressão
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
Idioma:
Inglês
Revista:
Biomedical and Environmental Sciences
Ano de publicação:
2014
Tipo de documento:
Artigo
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