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Molecular Characterization of the L Segment of Hantann Virus, Strain Howang
Journal of the Korean Society of Virology ; : 155-163, 1999.
Artigo em Coreano | WPRIM | ID: wpr-27131
ABSTRACT
Hantaan virus (HTNV), the etiologic agent of hemorrhagic fever with renal syndrome (HFRS), belongs to the genus Hantavirus, and has three single negative straded RNA genome segments. HTNV strain Howang isolated from the blood of severe case of Korean HFRS is more virulent than HTNV 76/118 and the M and S genome segments' nucleotide sequence of Howang strain showed 93.5% and 94% homology to each segment of HTNV 76/118. We have obtained 6533 nucleotides long sequence of the L genome segment of Howang strain using reverse transcriptase in conjunction with PCR amplification and compared to other hantaviruses. The messenger sense of the L segment contains one long single long open reading frame of 2151 amino acids, which encodes a deduced RNA dependent RNA polymerase of 246.4 kDa caculated molecular weight protein. The nucleotide sequence of the Lsegment of Howang strain shows 93%, 74%, 66%,65% homology to HTNV 76/118, Seoul virus 80/39, Puumala virus Hallnas B1 and Sin Nombre virus, respectively. The amino acid sequence of the L segment of Howang strain shows 99%, 85%, 68%, 68% homology to HTNV 76/118, Seoul virus 80/39, Puumala virus Hallnas B1 and Sin Nombre virus, respectively.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: RNA Polimerase Dependente de RNA / RNA / Sequência de Bases / Reação em Cadeia da Polimerase / Fases de Leitura Aberta / Sequência de Aminoácidos / DNA Polimerase Dirigida por RNA / Genoma / Orthohantavírus / Vírus Hantaan Idioma: Coreano Revista: Journal of the Korean Society of Virology Ano de publicação: 1999 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: RNA Polimerase Dependente de RNA / RNA / Sequência de Bases / Reação em Cadeia da Polimerase / Fases de Leitura Aberta / Sequência de Aminoácidos / DNA Polimerase Dirigida por RNA / Genoma / Orthohantavírus / Vírus Hantaan Idioma: Coreano Revista: Journal of the Korean Society of Virology Ano de publicação: 1999 Tipo de documento: Artigo