Interaction of bovine serum albumin with luteolin and apigenin / 药学学报
Acta Pharmaceutica Sinica
;
(12): 352-357, 2006.
Artigo
em Chinês
| WPRIM
| ID: wpr-271428
ABSTRACT
<p><b>AIM</b>To study the interaction mechanism of bovine serum albumin (BSA) with luteolin and apigenin.</p><p><b>METHODS</b>Fluorescence quenching method and non-radioactive energy transfer theory were used.</p><p><b>RESULTS</b>The binding constants at different temperature were determined and the quenching mechanism of them were suggested as static quenching. The transfer efficiency of energy and distance between BSA and luteolin or apigenin were investigated according to the mechanism of the Förster energy transference.</p><p><b>CONCLUSION</b>The interaction between them seems to be strong and the binding force were mainly hydrophobic force. B(3')-OH,B(4')-OH strengthened the interaction of flavonoids and BSA.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Ligação Proteica
/
Espectrometria de Fluorescência
/
Espectrofotometria Ultravioleta
/
Termodinâmica
/
Soroalbumina Bovina
/
Química
/
Apigenina
/
Luteolina
/
Transferência de Energia
Idioma:
Chinês
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2006
Tipo de documento:
Artigo
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