mRNA expression of voltage-dependent potassium channels in the brain of rats after middle cerebral artery occlusion / 药学学报
Acta Pharmaceutica Sinica
; (12): 328-332, 2006.
Article
em Zh
| WPRIM
| ID: wpr-271433
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>AIM</b>To study the mRNA expression changes in the brain of rats after middle cerebral artery occlusion.</p><p><b>METHODS</b>Middle cerebral artery occlusion was used to induce ischemia in rat brain. The mRNA expression of voltage-dependent potassium channel subtypes, including Kv1.4, Kv1.5, Kv2.1 and Kv4.2, were detected in rat hippocampus and cortex by RT-PCR.</p><p><b>RESULTS</b>Middle cerebral artery occlusion induced a significant neurological injury in rats. After ischemia 2 h, the mRNA of Kv1.4, Kv2.1 and Kv4.2 in hippocampus increased by 50%, 67% and 90% , respectively. And the mRNA of Kv1.4 and Kv4.2 maintained at a high level in hippocampus after ischemia 24 h. In cortex, the mRNA level of all the four subtypes were not changed significantly after ischemia 2 h, but the mRNA of Kv2.1 and Kv4.2 increased by 70% and 62% after ischemia 24 h, respectively.</p><p><b>CONCLUSION</b>The mRNA expression levels of voltage-dependent potassium channels were up-regulated in rat hippocampus and cortex after middle cerebral artery occlusion.</p>
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Encéfalo
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RNA Mensageiro
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Regulação para Cima
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Ratos Wistar
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Infarto da Artéria Cerebral Média
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Canais de Potássio de Abertura Dependente da Tensão da Membrana
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Canais de Potássio Shab
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Canais de Potássio Shal
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Genética
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Metabolismo
Limite:
Animals
Idioma:
Zh
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2006
Tipo de documento:
Article