Anticoagulant property of a semi-synthesized sodium beta-1,4-glucan sulfate / 药学学报
Acta Pharmaceutica Sinica
;
(12): 323-327, 2006.
Artigo
em Inglês
| WPRIM
| ID: wpr-271434
ABSTRACT
<p><b>AIM</b>To investigate the anticoagulant efficacy and mechanism of a semi-synthesized sodium beta-1,4-glucan sulfate (Na-MCS).</p><p><b>METHODS</b>Anticoagulant activity was evaluated by means of coagulation assays in comparison with heparin. The anticoagulant mechanism of Na-MCS was disclosed by inhibitory analysis of the activities of coagulation factors using chromogenic substrates.</p><p><b>RESULTS</b>0.6 microg x mL(-1) Na-MCS could significantly prolong APTT and TT, but has less effect on PT at an even higher concentration. The dosage of Na-MCS required to double APTT of normal human plasma was 0.7 microg x mL(-1), lower than that of heparin with the activity of 150 u x mg(-1).</p><p><b>CONCLUSION</b>Na-MCS represented a potent anticoagulation activity in vitro, which matched the efficacy of heparin in a certain range of concentrations. Na-MCS exhibited anticoagulant activity due to inhibition of the coagulation factors IIa and Xa by the mediation of anti-thrombin AT-III.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Tempo de Tromboplastina Parcial
/
Farmacologia
/
Tempo de Protrombina
/
Tempo de Trombina
/
Coagulação Sanguínea
/
Protrombina
/
Heparina
/
Fator Xa
/
Antitrombina III
/
Relação Dose-Resposta a Droga
Limite:
Humanos
Idioma:
Inglês
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2006
Tipo de documento:
Artigo
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