Inherited mutations of MUTYH and colorectal cancer / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
;
(6): 406-411, 2007.
Artigo
em Chinês
| WPRIM
| ID: wpr-271512
ABSTRACT
MUTYH, one of base-excision repair enzymes, is associated with human genetic disorders. Inherited biallelic mutations in the human MUTYH gene are responsible for an autosomal recessive syndrome-adenomatous colorectal polyposis (MUTYH associated polyposis, MAP), which significantly increases the risk of colorectal cancer (CRC). In this article we review the relationship between BER and the oxidative damage to DNA, the functional overlap of BER with other repair proteins, the molecular mechanism of tumourigenesis in MAP, and delineate the MUTYH polyposis phenotype and its prevention.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Dano ao DNA
/
Neoplasias Colorretais
/
Fatores de Risco
/
Mutação em Linhagem Germinativa
/
Polipose Adenomatosa do Colo
/
DNA Glicosilases
/
Genética
/
Mutação
Tipo de estudo:
Estudo de etiologia
/
Fatores de risco
Limite:
Humanos
Idioma:
Chinês
Revista:
Journal of Zhejiang University. Medical sciences
Ano de publicação:
2007
Tipo de documento:
Artigo
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