Advances in study of structures and functions of conantokins / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
;
(6): 204-208, 2007.
Artigo
em Chinês
| WPRIM
| ID: wpr-271548
ABSTRACT
Conantokin is a distinct family of conotoxin superfamily. Its members share considerable overall sequence homology. Their defining attributes include a high relative content of gamma-carboxyglutamic acid (Gla). They are generally devoid of disufide-loop contrasted with other conotoxins (except for conantokin-R). Upon binding to metal ions, the content of alpha-helix conformation increases in different degrees. They inhibit NMDA (N-methyl-D-aspartate) receptors; moreover, different conantokin species present different NMDA receptor subunit specificity. It can induce sleep-like symptoms in young mice when delivered intracranially. Analysis of sequences and structures indicates that the high conserved residues of these peptides are determinative in their structures and functions. In this article, the relationships of their structures and functions are reviewed in detail.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Peptídeos
/
Farmacologia
/
Fisiologia
/
Relação Estrutura-Atividade
/
Bloqueadores dos Canais de Cálcio
/
Química
/
Receptores de N-Metil-D-Aspartato
/
Conotoxinas
/
Venenos de Moluscos
Limite:
Humanos
Idioma:
Chinês
Revista:
Journal of Zhejiang University. Medical sciences
Ano de publicação:
2007
Tipo de documento:
Artigo
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