Investigation on NB4 cell responses to realgar by cDNA microarray / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 600-604, 2002.
Artigo
em Chinês
| WPRIM
| ID: wpr-271863
ABSTRACT
<p><b>OBJECTIVE</b>To elucidate the molecular mechanism of realgar-induced apoptosis and differentiation of acute promyelocytic leukemia(APL) cell line NB4.</p><p><b>METHOD</b>The response of NB4 cells to realgar was explored with a cDNA microarray representing 1003 different human genes.</p><p><b>RESULT</b>The analysis of gene expression profiles indicated that 9 genes were up-regulated and 37 genes were down-regulated. Among the 9 up-regulated genes, 2 genes were involved in proteasome degradation pathway.</p><p><b>CONCLUSION</b>PSMC2, PSMD1 and ITGB1 genes may play a role in the apoptosis and differentiation of NB4 cells.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Farmacologia
/
Arsenicais
/
Sulfetos
/
Materia Medica
/
Células Tumorais Cultivadas
/
Leucemia Promielocítica Aguda
/
Regulação da Expressão Gênica
/
Análise de Sequência com Séries de Oligonucleotídeos
/
Perfilação da Expressão Gênica
Limite:
Humanos
Idioma:
Chinês
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2002
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS