Relationship Between Essential Tremor and Cerebellar Dysfunction According to Age
Journal of Clinical Neurology
;
: 76-80, 2005.
Artigo
em Inglês
| WPRIM
| ID: wpr-27253
ABSTRACT
BACKGROUND:
The cerebellum and its neural circuitry have been assumed to play a major role in the pathophysiology of essential tremor (ET). In this study, we sought to find associations between ET and cerebellar dysfunction.METHODS:
We performed tandem gait test in 41 ET patients and 44 age-matched controls. Investigators assessed tandem gait by counting the number of missteps during ten-step tandem walk and each subject repeated the trial three times.RESULTS:
ET patients had a higher average and total numbers of missteps during tandem gait tests than control subjects (p or =70 years) showed significantly higher prevalence of tandem gait abnormality than young ones. Interaction terms determined by a likelihood ratio test was also statistically significant (p<0.05).CONCLUSIONS:
Dysfunction of cerebellar neural circuitry may be associated with the pathophysiological mechanism of ET. In addition, aging may be an important factor modifying the association.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Pesquisadores
/
Envelhecimento
/
Razão de Chances
/
Doenças Cerebelares
/
Cerebelo
/
Prevalência
/
Tremor Essencial
/
Marcha
Tipo de estudo:
Estudo de etiologia
/
Estudo de prevalência
Limite:
Humanos
Idioma:
Inglês
Revista:
Journal of Clinical Neurology
Ano de publicação:
2005
Tipo de documento:
Artigo
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