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Relationship between Calreticulin Gene Mutation and JAK2/MPL Negative Myeloproliferative Neoplasms / 中国实验血液学杂志
Journal of Experimental Hematology ; (6): 1532-1534, 2015.
Artigo em Chinês | WPRIM | ID: wpr-272567
ABSTRACT
In 2008, WHO made the JAK2V617F gene mutation as one of the specific molecular diagnostic markers of BCR/ABL-negative myeloproliferative neoplasms (MPN). In 2013 two research teams demonstrated that whole genome sequencing technology (WGS) was used to detect calreticulin gene mutation in essential thrombocythaemia (ET) and primary myelofibrosis (PMF) patients with JAK2V617F⁻ and MPL⁻ mutations. In this review, the relationship of CALR gene mutation with MPN is briefly summarized.
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Neoplasias da Medula Óssea / Calreticulina / Janus Quinase 2 / Receptores de Trombopoetina / Genética / Mutação / Transtornos Mieloproliferativos Limite: Humanos Idioma: Chinês Revista: Journal of Experimental Hematology Ano de publicação: 2015 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Neoplasias da Medula Óssea / Calreticulina / Janus Quinase 2 / Receptores de Trombopoetina / Genética / Mutação / Transtornos Mieloproliferativos Limite: Humanos Idioma: Chinês Revista: Journal of Experimental Hematology Ano de publicação: 2015 Tipo de documento: Artigo