Study rat nephrotoxicity of Longdan Xiegan Tang / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 785-788, 2004.
Artigo
em Chinês
| WPRIM
| ID: wpr-272799
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the nephrotoxocity of Longdan Xiegan Tang in rats, and to test its safety.</p><p><b>METHOD</b>Sprague-Dauley rats were given Longdan Xiegan Tang 4.5 mL x (100 mg)(-1) Bid for thirty days, and the control group was given NS. MTP, BUN, Cr, MDA, MTP/Ucr and SOD were measured on 1st, 2nd, 3rd, 4th week. The kidney tissues were viewed with light microscopy and electron microscope.</p><p><b>RESULT</b>MTP and MTP/Ucr were obviously higher than controls ( P < 0.01), and the other index had no difference (P > 0.05). No remarkable structural change could been seen with light microscopy, but with electron microscope we could find that the basal membranes were thickened and some of foot process were infused.</p><p><b>CONCLUSION</b>Longdan Xiegan Tang will result in injury of kidney function.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Plantas Medicinais
/
Proteinúria
/
Superóxido Dismutase
/
Membrana Basal
/
Sangue
/
Nitrogênio da Ureia Sanguínea
/
Medicamentos de Ervas Chinesas
/
Química
/
Ratos Sprague-Dawley
/
Magnoliopsida
Limite:
Animais
Idioma:
Chinês
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2004
Tipo de documento:
Artigo
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