Curative machanism of Shenle capsule on 5/6 nephrectomy rats / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 770-773, 2004.
Artigo
em Chinês
| WPRIM
| ID: wpr-272803
ABSTRACT
<p><b>OBJECTIVE</b>To explore curative machanism of Shenle capsule on the 5/6 nephrectomy rats.</p><p><b>METHOD</b>Fibrin plate method was applied to examine activity of urinary plasminogen activator(PA). Semi-quantitative analysis was used to observe stained intensity and area of tissue-type plasminogen activator, urokinas-type plasminogen activator/ plasminogen activator inhibitor(tPA, uPA/PAI-1)in remnant renal tissue. Northern blot was employed to analyze the expression of transforming growth factor (TGF-beta) mRNA.</p><p><b>RESULT</b>In model control group, the urinary PA activity and protein expression of tPA, uPA were down-regulated, but protein expression of PAI-1, TGF-beta mRNA was up-regulated in remnant renal tissue. In each treated group, the urinary PA activity and protein expression of tPA/uPA were enhanced,but the protein expression of PAI-1, TGF-beta mRNA decreased simultaneously.</p><p><b>CONCLUSION</b>Shenle capsule can delay glomerulosclersis and tubulointerstitial fibrotic lesions of remnant kidney by improving the activity of urinary PA and modulating the expression of tPA, uPA/PAI-1 and TGF-beta mRNA.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
RNA Mensageiro
/
Cápsulas
/
Medicamentos de Ervas Chinesas
/
Materia Medica
/
Ativador de Plasminogênio Tipo Uroquinase
/
Inativadores de Plasminogênio
/
Química
/
Fator de Crescimento Transformador beta
/
Ativador de Plasminogênio Tecidual
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
Idioma:
Chinês
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2004
Tipo de documento:
Artigo
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