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Changes of amino acid content in hippocampus of epileptic rats treated with volatile oil of Acorus tatarinowii / 中国中药杂志
China Journal of Chinese Materia Medica ; (24): 670-673, 2004.
Artigo em Chinês | WPRIM | ID: wpr-272826
ABSTRACT
<p><b>OBJECTIVE</b>To study the changes of excitatory and inhibitory amino acid content in hippocampus of epileptic rats treated with volatile oil of A. tatarinowii, and explore the possible antiepiletic mechanism.</p><p><b>METHOD</b>The volatile oil was extracted through Supercritical-CO2 Fluid Extraction (SFE-CO2), and epileptic models were built up by kainic acid (KA) lateral ventricle injection. The content of amino acid in hippocampus of epileptic rats treated with volatile oil was calculated.</p><p><b>RESULT</b>The content of GABA increased and Glu decreased prominently (P < 0.05) after volatile oil 35 mg x kg(-1) intraperitoneal injection.</p><p><b>CONCLUSION</b>The volatile oil of A. tatarinowii can modulate the balance of excitatory and inhibitory amino acid in epileptic rats, thereby exerting its antiepileptic effect.</p>
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Farmacologia / Plantas Medicinais / Óleos Voláteis / Química / Ratos Sprague-Dawley / Ácido Aspártico / Ácido Glutâmico / Acorus / Epilepsia / Ácido gama-Aminobutírico Limite: Animais Idioma: Chinês Revista: China Journal of Chinese Materia Medica Ano de publicação: 2004 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Farmacologia / Plantas Medicinais / Óleos Voláteis / Química / Ratos Sprague-Dawley / Ácido Aspártico / Ácido Glutâmico / Acorus / Epilepsia / Ácido gama-Aminobutírico Limite: Animais Idioma: Chinês Revista: China Journal of Chinese Materia Medica Ano de publicação: 2004 Tipo de documento: Artigo