Preparation of liposomes surface-modified with glycyrrhetinic acid targeting to hepatocytes / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To study the preparation of liposomes surface-modified with glycyrrhetinic acid targeting to hepatocytes.</p><p><b>METHOD</b>3-succinic-30-stearyl glycyrrhetinic acid(Suc-GAOSt), one of the amphiphilic glycyrrhetinic acid derivatives, was synthesized as targeting molecules, liposomes surface-modified with glycyrrhetinic acid has been produced with ethanol injection method.</p><p><b>RESULT</b>Targeting molecules can be mixed into the liposomal membrane. It was confirmed that the targeting molecules is 9% of the total lipids at the most in the liposomes.</p><p><b>CONCLUSION</b>Liposomes surface-modified with glycyrrhetinic acid was successfully prepared, which is considered to be a potential approach targeting to hepatocytes.</p>