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Sclerosing angiomatoid nodular transformation of spleen: a clinicopathologic study of 10 cases with review of literature / 中华病理学杂志
Chinese Journal of Pathology ; (12): 84-87, 2010.
Artigo em Chinês | WPRIM | ID: wpr-273451
ABSTRACT
<p><b>OBJECTIVE</b>To study the clinicopathologic features, differential diagnosis and pathogenesis of sclerosing angiomatoid nodular transformation of spleen.</p><p><b>METHODS</b>Ten cases of sclerosing angiomatoid nodular transformation of spleen were retrieved from the archival file. Histochemical and immunohistochemical (EnVision method) studies were performed. Ultrastructural findings were also available in one of them.</p><p><b>RESULTS</b>Sclerosing angiomatoid nodular transformation was characterized by micronodular appearance of vascular spaces lined by plump endothelial cells with interspersed ovoid spindle cells. Immunohistochemical study showed that the endothelial cells of vessels in the angiomatoid nodules had various expressions of immunologic phenotypes and could be mainly classified into 3 types CD34(+)/CD31(+)/CD8⁻ endothelial cells of the capillaries, CD8(+)/CD31(+)/CD34⁻ lining cells of the sinusoids and CD31(+)/CD8⁻/CD34⁻ endothelial cells of the small veins. Collagen network and dilated lymphatic sinuses were evident under transmission electron microscope.</p><p><b>CONCLUSIONS</b>Sclerosing angiomatoid nodular transformation of spleen is a rare benign entity. It may represent a reactive condition and bears some relationship with splenic angioma. It needs to be distinguished from borderline or malignant vascular tumors of spleen.</p>
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Patologia / Neoplasias Esplênicas / Cirurgia Geral / Microscopia Eletrônica / Antígenos CD8 / Histiocitoma Fibroso Benigno / Antígenos CD34 / Molécula-1 de Adesão Celular Endotelial a Plaquetas / Diagnóstico Diferencial / Hemangioendotelioma Tipo de estudo: Estudo diagnóstico Limite: Adulto / Feminino / Humanos / Masculino Idioma: Chinês Revista: Chinese Journal of Pathology Ano de publicação: 2010 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Patologia / Neoplasias Esplênicas / Cirurgia Geral / Microscopia Eletrônica / Antígenos CD8 / Histiocitoma Fibroso Benigno / Antígenos CD34 / Molécula-1 de Adesão Celular Endotelial a Plaquetas / Diagnóstico Diferencial / Hemangioendotelioma Tipo de estudo: Estudo diagnóstico Limite: Adulto / Feminino / Humanos / Masculino Idioma: Chinês Revista: Chinese Journal of Pathology Ano de publicação: 2010 Tipo de documento: Artigo