The effects of newly formed synthetic peptide on bone regeneration in rat calvarial defects
Journal of Periodontal & Implant Science
;
: 11-18, 2010.
Artigo
em Inglês
| WPRIM
| ID: wpr-27388
ABSTRACT
PURPOSE:
Significant interest has emerged in the design of cell scaffolds that incorporate peptide sequences that correspond to known signaling domains in extracellular matrix and bone morphogenetic protein. The purpose of this study was to evaluate the bone regenerative effects of the synthetic peptide in a critical-size rat calvarial defect model.METHODS:
Eight millimeter diameter standardized, circular, transosseus defects created on the cranium of forty rats were implanted with synthetic peptide, collagen, or both synthetic peptide and collagen. No material was was implanted the control group. The healing of each group was evaluated histologically and histomorphometrically after 2- and 8-week healing intervals.RESULTS:
Surgical implantation of the synthetic peptide and collagen resulted in enhanced local bone formation at both 2 and 8 weeks compared to the control group. When the experimental groups were compared to each other, they showed a similar pattern of bone formation. The defect closure and new bone area were significantly different in synthetic peptide and collagen group at 8 weeks.CONCLUSIONS:
Concerning the advantages of biomaterials, synthetic peptide can be an effective biomaterial for damaged periodontal regeneration.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Osteogênese
/
Regeneração
/
Crânio
/
Materiais Biocompatíveis
/
Regeneração Óssea
/
Colágeno
/
Proteínas Morfogenéticas Ósseas
/
Matriz Extracelular
Limite:
Animais
Idioma:
Inglês
Revista:
Journal of Periodontal & Implant Science
Ano de publicação:
2010
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS