Sequence Analysis of A Novel HLA-B*13:68 Allele / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 1144-1146, 2015.
Artigo
em Chinês
| WPRIM
| ID: wpr-274078
ABSTRACT
<p><b>OBJECTIVE</b>The purpose of this research was to identify a novel HLA-B allele in Chinese population.</p><p><b>METHODS</b>The HLA typing of bone marrow donors was performed by PCR-SBT. The ambiguous novel HLA allele was confirmed with GSSP method.</p><p><b>RESULTS</b>The sequence of a sample was different from all alleles in the HLA-B databases. The sequence analysis showed that it differed from the closet matching allele HLA-B*130101 at one nucleotide substitution, 137 T > C in Exon2, which resulted in an amino acid change from Phenylalanine (Phe) to Serine (Ser) at codon 22.</p><p><b>CONCLUSION</b>A novel allele was identified and named as HLA-B*1368 by the WHO Nomenclature Committee.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Teste de Histocompatibilidade
/
Sequência de Bases
/
Antígenos HLA-B
/
Reação em Cadeia da Polimerase
/
Análise de Sequência de DNA
/
Povo Asiático
/
Alelos
Limite:
Humanos
Idioma:
Chinês
Revista:
Journal of Experimental Hematology
Ano de publicação:
2015
Tipo de documento:
Artigo
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