Expression of secretoglobin family 2A member 2 in oral lichen planus lesions / 中华口腔医学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To examine the expression of secretoglobin family 2A member 2 (SCGB2A2) (mammaglobin A, MGB1) in oral lichen planus (OLP) lesions.</p><p><b>METHODS</b>Sixteen OLP patients and 10 healthy controls were included in this study. The real time reverse transcription-PCR (RT-PCR), Western blotting and immunohistochemistry (IHC) were used to determine the mRNA and protein of SCGB2A2.</p><p><b>RESULTS</b>Compared with healthy controls (0.48 ± 0.09), the expression of SCGB2A2 protein in OLP lesions significantly increased (1.02 ± 0.11) (P < 0.05).However, the mRNA level of SCGB2A2 in lesions was significantly lower than that in controls (P < 0.05).</p><p><b>CONCLUSIONS</b>These results suggest that SCGB2A2 may be involved in pathogenesis of OLP.</p>