Phamacokinetic study of bergapten in rats plasma by LC-MS/MS / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 381-383, 2012.
Article
em Zh
| WPRIM
| ID: wpr-274338
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To determine bergapten's concentration in plasma and observe its pharmacokinetics in rats using a combined LC-MS/MS analytical method.</p><p><b>METHOD</b>Blood samples were separated on a Hypersil ODS column (4.6 mm x 250 mm, 5 mm) at a temperature of 30 degrees C, and mobile phase consisted of water and methanol (22.5: 77.5) at a flow rate of 0.8 mL x min(-1).</p><p><b>RESULT</b>The methodological study showed a good linear relationship of 8.12-162.4 g x L(-1) (r = 0.9999). The inner and inter-days relative standard deviations were both less than 10% , indicating legitimate precise and accuracy to the requirement of biological sample analysis.</p><p><b>CONCLUSION</b>The method is suitable for in vivo quantitative analysis for bergapten due to its accuracy, sensitivity and specificity. The pharmacokinetic process in rats forms a two-compartment model with first-order absorption.</p>
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Valores de Referência
/
Fatores de Tempo
/
Sangue
/
Farmacocinética
/
Reprodutibilidade dos Testes
/
Cromatografia Líquida
/
Sensibilidade e Especificidade
/
Ratos Sprague-Dawley
/
Espectrometria de Massas em Tandem
/
Metoxaleno
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Animals
Idioma:
Zh
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2012
Tipo de documento:
Article