Study on andrographolide-induced apoptosis of Candida albicans biofilm dispersion cells / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 362-365, 2012.
Artigo
em Chinês
| WPRIM
| ID: wpr-274342
ABSTRACT
<p><b>OBJECTIVE</b>To detect the effect of andrographolide on apoptosis of Candida albicans biofilm dispersion cells.</p><p><b>METHOD</b>The morphological changes of apoptotic C. albicans biofilm cells were observed by using Hoechst 33258 staining Fluorescence microscope; changes of mitochondrial membrane potential (MMP) of C. albicans biofilm cells were detected by rhodamine 123 staining flow cytometry; and reactive oxygen species (ROS) was detected by DHR staining flow cytometry.</p><p><b>RESULT</b>1 000, 100 micromol x L(-1) of andrographolide could cause pyknosis and dense staining of C. albicans biofilm cells, 1 000, 100, 10 micromol x L(-1) of andrographolide could decrease MMP and increase ROS of C. albicans biofilm cells.</p><p><b>CONCLUSION</b>Andrographolide of appropriate concentrations could induce apoptosis of dispersion cells of C. albicans biofilms.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Fisiologia
/
Candida albicans
/
Espécies Reativas de Oxigênio
/
Apoptose
/
Biofilmes
/
Diterpenos
/
Potencial da Membrana Mitocondrial
/
Metabolismo
/
Antifúngicos
Idioma:
Chinês
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2012
Tipo de documento:
Artigo
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