Progress in the fragment-based drug discovery / 药学学报
Acta Pharmaceutica Sinica
;
(12): 14-24, 2013.
Artigo
em Chinês
| WPRIM
| ID: wpr-274596
ABSTRACT
As an extension of the structure-based drug discovery, fragment-based drug discovery is matured increasingly, and plays an important role in drug development. Fragments in a small library, with lower molecular mass and high "ligand efficiency", are detected by SPR, MS, NMR, X-ray crystallography technologies and other biophysical methods. Then they are considered as starting points for chemical optimization with the guidance of structural biology methods to get good "drug-like" lead and candidate compounds. In this article, we reviewed the current progress of fragment-based drug discovery and detailed a number of examples to illustrate the novel strategies.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fragmentos de Peptídeos
/
Conformação Proteica
/
Espectroscopia de Ressonância Magnética
/
Química
/
Desenho Assistido por Computador
/
Cristalografia por Raios X
/
Ressonância de Plasmônio de Superfície
/
Bibliotecas de Moléculas Pequenas
/
Descoberta de Drogas
/
Ligantes
Idioma:
Chinês
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2013
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS