Identification of metabolites of arbidol by ultra-high performance liquid chromatography tandem mass spectrometry / 药学学报
Acta Pharmaceutica Sinica
;
(12): 1521-1526, 2012.
Artigo
em Chinês
| WPRIM
| ID: wpr-274628
ABSTRACT
UPLC-MS-MS system was used for the identification of arbidol metabolites in the rat feces, urine and plasma samples. The system was so powerful a way with high ability of separation and analysis, based on both chromatography and mass properties. The isotope of Br was also a good indicator for metabolites finding. There were altogether 9 metabolites detected and identified, including 2 phase I biotransformation products and 7 phase II ones. It is concluded that arbidol mainly undergo metabolic reactions such as N-demethylation, S-oxidation, glucuronidation and sulfation in rats.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Urina
/
Sangue
/
Farmacocinética
/
Biotransformação
/
Química
/
Cromatografia Líquida de Alta Pressão
/
Ratos Wistar
/
Espectrometria de Massas em Tandem
/
Fezes
/
Indóis
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
Idioma:
Chinês
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2012
Tipo de documento:
Artigo
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