Synthesis and biological evaluation of noscapine analogues as microtubule-interfering agents / 药学学报
Acta Pharmaceutica Sinica
;
(12): 1347-1357, 2012.
Artigo
em Inglês
| WPRIM
| ID: wpr-274655
ABSTRACT
A series of noscapine analogues have been synthesized via 13-step reaction starting from 2-hydroxy-3-methoxybenzaldehyde. Anti-tumor activities of these compounds were evaluated against HL-60 cell lines in vitro by the standard MTT assay. It was found that most of these derivatives showed appreciable inhibitory activity against HL-60 and tubulin polymerization. The results also indicated that the potency of compound 31 is about three times more than that ofnoscapine against HL-60 cell line and tubulin polymerization. Moreover, it induced a massive accumulation of cells in G2/M phase. These results showed noscapine and its derivatives were worth to be intensively studied further.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Tubulina (Proteína)
/
Ciclo Celular
/
Células HL-60
/
Moduladores de Tubulina
/
Polimerização
/
Metabolismo
/
Antineoplásicos
/
Noscapina
Limite:
Humanos
Idioma:
Inglês
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2012
Tipo de documento:
Artigo
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