An experimental study of the anticonvulsant effect of amlodipine in mice
Singapore medical journal
;
: 424-428, 2010.
Artigo
em Inglês
| WPRIM
| ID: wpr-274792
ABSTRACT
<p><b>INTRODUCTION</b>The need for the rational development of newer and adjuvant drugs to treat epilepsy has prompted this study of the potential anticonvulsant effect of amlodipine.</p><p><b>METHODS</b>The acute effect was studied in mice in single doses of 1 mg/kg, 2 mg/kg and 4 mg/kg of amlodipine and the chronic effect was studied in doses of 1 mg/kg and 4 mg/kg (administered daily for 21 days) using the maximal electroshock seizure and pentylenetetrazole-induced seizure models of epilepsy. Sodium valproate and normal saline were used as the standard and control, respectively.</p><p><b>RESULTS</b>For the acute study, in the maximal electroshock seizure model, the administration of 1 mg/kg of amlodipine resulted in the complete abolition of seizures in 33 percent of the mice, and this was increased to 67 percent with the administration of 4 mg/kg. In the pentylenetetrazole-induced seizure model, the administration of 1 mg/kg and 2 mg/kg amlodipine protected 33 percent of the animals from mortality, and 67 percent were protected with the administration of 4 mg/kg. For the chronic study, in the maximal electroshock seizure model, the administration of 1 mg/kg amlodipine resulted in the complete abolition of seizures in 40 percent of the mice and in 60 percent, with the administration of 4 mg/kg. In the pentylenetetrazole-induced seizure model, 50 percent of the mice were protected from mortality with 1 mg/kg amlodipine and 60 percent, with 4 mg/kg amlodipine.</p><p><b>CONCLUSION</b>These findings indicate that amlodipine may be a good candidate as an add-on therapy for epilepsy.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Pentilenotetrazol
/
Convulsões
/
Fatores de Tempo
/
Bloqueadores dos Canais de Cálcio
/
Ácido Valproico
/
Anlodipino
/
Convulsivantes
/
Usos Terapêuticos
/
Modelos Animais de Doenças
/
Tratamento Farmacológico
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
Idioma:
Inglês
Revista:
Singapore medical journal
Ano de publicação:
2010
Tipo de documento:
Artigo
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