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Research progress of tumor cell migration strategy and the migration transition mechanism / 生物医学工程学杂志
Journal of Biomedical Engineering ; (6): 1251-1256, 2011.
Artigo em Chinês | WPRIM | ID: wpr-274916
ABSTRACT
Tumor cells exhibit two main different migration strategies when invading in 3D environment, i. e. mesenchymal migration and amoeboid migration. This review summarizes the internal reasons and characteristics on various modes of migration adaptation to the microenvironment, and the molecular mechanisms in particular environment where they are mutually interchangeable. A study of the mechanisms that may possibly trigger mesenchymal-amoeboid transition/amoeboid-mesenchymal transition help us to understand the change and the plasticity in the migration strategies of tumor cells. These are important for the development of a cancer treatment, which would efficiently suppress tumor cell invasiveness.
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Patologia / Fisiologia / Integrinas / Movimento Celular / Matriz Extracelular / Invasividade Neoplásica / Metástase Neoplásica Limite: Humanos Idioma: Chinês Revista: Journal of Biomedical Engineering Ano de publicação: 2011 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Patologia / Fisiologia / Integrinas / Movimento Celular / Matriz Extracelular / Invasividade Neoplásica / Metástase Neoplásica Limite: Humanos Idioma: Chinês Revista: Journal of Biomedical Engineering Ano de publicação: 2011 Tipo de documento: Artigo