Studies on anti-endotoxin activity of F022 from Radix Isatidis / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 439-442, 2002.
Artigo
em Chinês
| WPRIM
| ID: wpr-274966
ABSTRACT
<p><b>OBJECTIVE</b>To study the anti-endotoxin activity and mechanism of F022 from Radix Isatidis.</p><p><b>METHOD</b>The production of TNF-alpha and IL-6 of murine peritoneal macrophages stimulated by LPS was measured by ELISA. The temperature in rabbits was tested after i.v. administration of LPS. The lethality of BCG-primed mice was induced by LPS.</p><p><b>RESULT</b>If F022 was added to macrophages culture simultaneously with LPS or 1 h before addition of LPS, production of TNF-alpha and IL-6 by macrophages was remarkably inhibited in vitro. F022 inhibited the fever induced by LPS in rabbits and protected BCG-primed mice from LPS induced lethality if given before administration of LPS.</p><p><b>CONCLUSION</b>The anti-endotoxin effect of F022 may inhibit LPS binding to its receptor, and it may be a LPS receptor antagonist.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Plantas Medicinais
/
Medicamentos de Ervas Chinesas
/
Química
/
Lipopolissacarídeos
/
Interleucina-6
/
Fator de Necrose Tumoral alfa
/
Macrófagos Peritoneais
/
Raízes de Plantas
/
Secreções Corporais
Limite:
Animais
Idioma:
Chinês
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2002
Tipo de documento:
Artigo
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