Influence of the watery extract of jiangzhining decoction on the genetic expression of hepatocyte LDLR of hyperlipidemic rats / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 289-301, 2002.
Artigo
em Chinês
| WPRIM
| ID: wpr-275007
ABSTRACT
<p><b>OBJECTIVE</b>To study the influence of Jiangzhining decoction on the genetic expression of Liver LDLR of the rats suffered from hyperlipemia.</p><p><b>METHOD</b>Laboratory animals were male wister rats with hyperlipemia resulting from high fat feeding. Prescription was the douche of stomach with Jiangzhining decoction (200%) with a dosage of 1.4 g.kg-1, for 15 successive days. Total RNA was extracted from the liver tissue of treated rats and LDLRmRNA was detected by Dot blot hybridization. Expression levels of LDLRmRNA was estimated by a ratio of LDLRmRNA and beta-actin mRNA.</p><p><b>RESULT</b>The difference between expression levels of LDLRmRNA for normal group and those for hyperlipemia group (100% +/- 19% vs 39% +/- 14%) was significant (P < 0.05); and the difference between decoction group (108 +/- 8%) and hyperlipimia group was also highly significant (P < 0.01).</p><p><b>CONCLUSION</b>High fat feeding reduces the expression of liver LDLRmRNA while the decoction can greatly increase it. The study and development of Jiangzhining are significant in preventing and curing cadiocerebral diseases.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
RNA Mensageiro
/
Receptores de LDL
/
Medicamentos de Ervas Chinesas
/
Actinas
/
Ratos Wistar
/
Combinação de Medicamentos
/
Genética
/
Hiperglicemia
/
Hipoglicemiantes
Limite:
Animais
Idioma:
Chinês
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2002
Tipo de documento:
Artigo
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