In vivo pro- and anti-inflammatory cytokines in normal and patients with rheumatoid arthritis
Annals of the Academy of Medicine, Singapore
;
: 96-99, 2007.
Artigo
em Inglês
| WPRIM
| ID: wpr-275224
ABSTRACT
<p><b>INTRODUCTION</b>Rheumatoid arthritis (RA) is a chronic, deforming arthritis that can lead to disabilities and poor quality of life. Cytokines are protein mediators of inflammation and are produced as a result of the activation of various cellular reactions. They are the final mediators and/or regulators of the inflammatory process.</p><p><b>MATERIALS AND METHODS</b>The sera from 64 RA patients were assayed for both Th-1 and Th-2 related cytokines and soluble TNF-alpha receptors (IFN-gamma, TGF-beta, TNF-alpha, IL-1beta, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12, IL-18, sTNF-R1 and sTNFR2) using ELISA.</p><p><b>RESULTS</b>The pro-inflammatory cytokines (IL-1, IL-6, IL-8, IL-18 and TNF- alpha) were significantly elevated in RA patients, while TGF-beta, an immunomodulatory cytokine, was elevated in control individuals. When the RA patients were categorised as active or inactive based on DAS scores, similar cytokines profiles were observed in both RA sub-groups. However, assays of sTNF-R1 and sTNFR-2 were noted to be significantly elevated in inactive RA patients when compared to active patients.</p><p><b>CONCLUSION</b>Our findings indicate that local production of cytokine inhibitors is capable of diminishing disease activity and cytokine activity.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Artrite Reumatoide
/
Sangue
/
Diferenciação Celular
/
Química
/
Citocinas
/
Fator de Crescimento Transformador beta
/
Receptores Tipo I de Fatores de Necrose Tumoral
/
Receptores Tipo II do Fator de Necrose Tumoral
Limite:
Adulto
/
Idoso
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Annals of the Academy of Medicine, Singapore
Ano de publicação:
2007
Tipo de documento:
Artigo
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