Human HSF1 mutants and their applications / 生物工程学报
Chinese Journal of Biotechnology
;
(12): 971-975, 2007.
Artigo
em Chinês
| WPRIM
| ID: wpr-276177
ABSTRACT
Heat shock factor 1 (HSF1) is the key protein in regulating stress response. It can be activated under heat, oxidative or another stress conditions. Dominant-positive and dominant-negative HSF1 are two types of HSF1 mutants. Both of them gain the DNA binding activity in the absence of stress. In addition, dominant-positive HSF1 acquires transcriptional activity, which dominant-negative HSF1 does not acquire. In this paper, the progress of using these HSF1 mutants in the research of cancer, neurodegenerative disorders and cardiovascular diseases will be discussed.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Terapêutica
/
Terapia Genética
/
Doenças Neurodegenerativas
/
Usos Terapêuticos
/
Proteínas Mutantes
/
Genética
/
Proteínas de Choque Térmico
/
Neoplasias
Limite:
Humanos
Idioma:
Chinês
Revista:
Chinese Journal of Biotechnology
Ano de publicação:
2007
Tipo de documento:
Artigo
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