Advance in the study of targeting delivery system for siRNA mediated by aptamers / 药学学报
Acta Pharmaceutica Sinica
;
(12): 850-855, 2012.
Artigo
em Chinês
| WPRIM
| ID: wpr-276233
ABSTRACT
RNA interference (RNAi), as a new technology of gene therapy, has been used in the studies of many diseases in vitro, however, targeting delivery of small interference RNA (siRNA) is still a bottleneck for clinical therapy of siRNA agents. Aptamer is a group of oligonucleotides with high affinity and targeting, and is becoming another important means of delivery for siRNA. In this review, we summarized siRNA delivery obstacles in vivo and recent attractive developments increatively using cell-internalizing aptamers to deliver siRNAs to target cells.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Terapêutica
/
Sistemas de Liberação de Medicamentos
/
RNA Interferente Pequeno
/
Interferência de RNA
/
Aptâmeros de Nucleotídeos
/
Técnica de Seleção de Aptâmeros
/
Metabolismo
/
Métodos
/
Neoplasias
Limite:
Humanos
Idioma:
Chinês
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2012
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS