Research progress of the atypical kinetic profiles of cytochrome P450 enzymes / 药学学报
Acta Pharmaceutica Sinica
;
(12): 725-729, 2012.
Artigo
em Chinês
| WPRIM
| ID: wpr-276253
ABSTRACT
Cytochrome P450 enzymes are composed of many isozymes and involved in the biotransformation of both exogenous and endogenous substances. A growing number of studies have found that the P450 enzymes do not always follow the classical Michaelis-Menten kinetics, but show atypical kinetic behavior, which is also the current research hotspot. In this paper, the category and mechanisms of atypical kinetics of the P450 enzyme were reviewed, providing theoretical basis for the research of enzyme kinetics.
Texto completo:
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Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Ligação Proteica
/
Especificidade por Substrato
/
Benzoflavonas
/
Sítios de Ligação
/
Cinética
/
Química
/
Sistema Enzimático do Citocromo P-450
/
Ativação Enzimática
/
Citocromo P-450 CYP3A
Limite:
Animais
/
Humanos
Idioma:
Chinês
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2012
Tipo de documento:
Artigo
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