Research progress of sodium-glucose co-transporter 2 inhibitors for treatment of type 2 diabetes / 药学学报
Acta Pharmaceutica Sinica
;
(12): 716-724, 2012.
Artigo
em Chinês
| WPRIM
| ID: wpr-276254
ABSTRACT
Sodium-glucose co-transporters are a family of glucose transporter found in the intestinal mucosa of the small intestine (SGLT-2) and the proximal tubule of the nephron (SGLT-1 and SGLT-2). They contribute to renal glucose reabsorption and most of renal glucose (about 90%) is reabsorbed by SGLT-2 located in the proximal renal tubule. Selectively inhibiting activity of SGLT-2 is an innovative therapeutic strategy for treatment of type 2 diabetes by enhancing urinary glucose excretion from the body. Therefore SGLT-2 inhibitors are considered to be potential antidiabetic drugs with an unique mechanism. This review will highlight some recent advances and structure-activity relationships in the discovery and development of SGLT-2 inhibitors including O-glycoside, C-glycoside, C, O-spiro glycoside and non glycosides.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Relação Estrutura-Atividade
/
Compostos Benzidrílicos
/
Estrutura Molecular
/
Química
/
Diabetes Mellitus Tipo 2
/
Tratamento Farmacológico
/
Transportador 1 de Glucose-Sódio
/
Transportador 2 de Glucose-Sódio
/
Glucosídeos
Limite:
Animais
/
Humanos
Idioma:
Chinês
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2012
Tipo de documento:
Artigo
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