Brucine chitosan thermosensitive hydrogel for intra-articular injection / 药学学报
Acta Pharmaceutica Sinica
;
(12): 652-656, 2012.
Artigo
em Chinês
| WPRIM
| ID: wpr-276264
ABSTRACT
The aim of this study was to develop a sustained release converse thermosensitive hydrogel for intra-articular injection using chitosan-glycerol-borax as matrix, its physical properties and biocompatibility were investigated. Taking gelation time and gelation condition as index, the influence of concentration of chitosan, ratio of chitosan to glycerol, pH on physical properties of hydrogel were investigated. And then the in vitro drug release, rheological properties and biocompatibility were studied. The thermosensitive hydrogel flows easily at room temperature and turns to gelation at body temperature, which can certainly prolong the release of drug and has good biocompatibility.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Plantas Medicinais
/
Reologia
/
Sementes
/
Estricnina
/
Propriedades de Superfície
/
Membranas Sinápticas
/
Temperatura
/
Teste de Materiais
/
Química
/
Ratos Sprague-Dawley
Limite:
Animais
Idioma:
Chinês
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2012
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS