An overview of biomarkers in Alzheimer's disease / 药学学报
Acta Pharmaceutica Sinica
;
(12): 551-557, 2012.
Artigo
em Chinês
| WPRIM
| ID: wpr-276281
ABSTRACT
Alzheimer's disease (AD), also called presenile dementia, is one of the most common neurodegenerative diseases in elderly people. The main pathological features of AD include senile plaques (SPs), neurofibrillary tangles (NFTs) and neuron loss. A biomarker is a characteristic that can be objectively measured and evaluated as an indicator of normal biological processes, pathogenic processes, or pharmacological responses to a therapeutic intervention. Class biomarkers of AD such as Abeta and phosphorylated tau have been widely used in clinical diagnosis of AD patients. Recently, novel technologies like proteomics, genomics, and imaging techniques have expanded the role of a biomarker from early diagnosis to monitoring the progression of diseases and evaluating the response to various treatments. In this article, we will review the progress of various biomarkers of AD.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fragmentos de Peptídeos
/
Fosforilação
/
Sangue
/
Diagnóstico por Imagem
/
Biomarcadores
/
Líquido Cefalorraquidiano
/
Alfa 1-Antitripsina
/
Peptídeos beta-Amiloides
/
Proteínas tau
/
Fluordesoxiglucose F18
Tipo de estudo:
Estudo diagnóstico
/
Estudo de rastreamento
Limite:
Humanos
Idioma:
Chinês
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2012
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS