Relationship between genetic polymorphisms of N-acetyltransferase and susceptibility to hepatocellular carcinoma / 中华肝脏病杂志
Chinese Journal of Hepatology
;
(12): 20-22, 2003.
Artigo
em Chinês
| WPRIM
| ID: wpr-276515
ABSTRACT
<p><b>OBJECTIVE</b>To study the possible relationship between genetic polymorphism of N-acetyltransferase 2 (NAT2) and susceptibility to hepatocellular carcinoma.</p><p><b>METHODS</b>Genetic polymorphisms of the four NAT2 genes in 78 patients with hepatocellular carcinoma and 112 healthy controls were analyzed by means of real-time fluorescence light-Cycler. The difference in frequencies between the hepatocellular carcinoma patients and the controls were compared.</p><p><b>RESULTS</b>The significant difference in slow acetylation genotype frequency was found between the controls and the hepatocellular carcinoma patients who were smokers (17.9% vs 37.5%, x(2)= 4.67, P<0.05) resulting in increased by 2.76 times the risk for hepatocellular carcinoma, but no evident difference between the controls and hepatocellular carcinoma patients who were non-smokers.</p><p><b>CONCLUSION</b>The smokers with slow acetylation genotype of N-acetyltransferase 2 may be the population with high risk for hepatocellular carcinoma.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Polimorfismo Genético
/
Acetilação
/
Arilamina N-Acetiltransferase
/
Fumar
/
Carcinoma Hepatocelular
/
Predisposição Genética para Doença
/
Genética
/
Genótipo
/
Neoplasias Hepáticas
Limite:
Adulto
/
Idoso
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Hepatology
Ano de publicação:
2003
Tipo de documento:
Artigo
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