Relationship between type I autoimmune hepatitis and alleles of HLA-DRB1 in Chinese patients of Shanghai area / 中华肝脏病杂志
Chinese Journal of Hepatology
;
(12): 347-349, 2002.
Artigo
em Chinês
| WPRIM
| ID: wpr-276572
ABSTRACT
<p><b>OBJECTIVE</b>To analyze the association between alleles of HLA-DRB1 and type I autoimmune hepatitis (AIH) in patients from Shanghai, China.</p><p><b>METHODS</b>In 32 Chinese patients with type I AIH and 48 healthy controls in Shanghai area, polymerase chain reaction amplification with sequence-specific primers (PCR-SSP) was performed to examine the association of the alleles of HLA-DRB1 and its subtypes with type I AIH.</p><p><b>RESULTS</b>HLA-DRB1 typing by PCR-SSP showed that DR4 had a significantly increased frequency among patients with AIH versus healthy control (46.9% versus 20.8%; relative risk=3.35, chi(2)=5.99, P=0.014). No other alleles differed significantly between the two groups. In subtypes of DRB1*04, there was a trend for an increase in gene frequency of DRB1*0405 increased in patients with type I AIH versus healthy controls (21.9% vs 6.3%, chi(2)=4.23, P=0.04, but Pc=0.08). The frequency of arginine at position HLA-DR beta 71 of third hypervariable region significantly increased among patients with AIH versus healthy control (46.9% versus 18.8%, chi(2)=7.14, P=0.008).</p><p><b>CONCLUSIONS</b>Type I AIH in Chinese patients of Shanghai area is associated with HLA-DR4 and arginine at position DR beta 71 of third hypervariable region</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Antígeno HLA-DR4
/
China
/
Reação em Cadeia da Polimerase
/
Primers do DNA
/
Hepatite Autoimune
/
Povo Asiático
/
Alelos
/
Cadeias HLA-DRB1
/
Frequência do Gene
/
Genética
Tipo de estudo:
Estudo de etiologia
Limite:
Humanos
País/Região como assunto:
Ásia
Idioma:
Chinês
Revista:
Chinese Journal of Hepatology
Ano de publicação:
2002
Tipo de documento:
Artigo
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