Enhanced absorption of breviscapine photosomes in small intestine of rats / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 222-225, 2005.
Artigo
em Chinês
| WPRIM
| ID: wpr-276607
ABSTRACT
<p><b>OBJECTIVE</b>To investigate whether the absorption of breviscapine can be enhanced by using breviscapine photosomes.</p><p><b>METHOD</b>Testing the uptake and intestinal permeability of breviscapine powder and breviscapine photosomes by using intestine perfusion technique and reverted gut sac method.</p><p><b>RESULT</b>The uptake and permeability coefficient of breviscapine were increased in photosomes. The absorption process obeyed the Fick's law in the range of 0-100 microg x mL(-1).</p><p><b>CONCLUSION</b>The absorption breviscapine photosomes is enhanced by increasing the permeability through a passive mechanism.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fosfolipídeos
/
Plantas Medicinais
/
Flavonoides
/
Portadores de Fármacos
/
Farmacocinética
/
Química
/
Ratos Sprague-Dawley
/
Asteraceae
/
Absorção Intestinal
/
Intestino Delgado
Limite:
Animais
Idioma:
Chinês
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2005
Tipo de documento:
Artigo
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