Cyclophilin A: A Mediator of Cardiovascular Pathology
Journal of the Korean Society of Hypertension
; : 133-147, 2011.
Article
em En
| WPRIM
| ID: wpr-27661
Biblioteca responsável:
WPRO
ABSTRACT
Cyclophilin A (CyPA) is a 17 kDa, ubiquitously expressed multifunctional protein that possesses peptidylprolyl cis-trans isomerase activity and scaffold function. Its expression is increased in inflammatory conditions including rheumatoid arthritis, autoimmune disease and cancer. Intracellular CyPA regulates protein trafficking, signal transduction, transcription regulation and the activity of certain other proteins. Secreted CyPA activates cardiovascular cells resulting in a variety of cardiovascular diseases; including vascular remodeling, abdominal aortic aneurysms formation, atherosclerosis, cardiac hypertrophy and myocardial ischemic reperfusion injury.
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Texto completo:
1
Índice:
WPRIM
Assunto principal:
Artrite Reumatoide
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Doenças Autoimunes
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Doenças Cardiovasculares
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Traumatismo por Reperfusão Miocárdica
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Transdução de Sinais
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Proteínas
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Aneurisma da Aorta Abdominal
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Cardiomegalia
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Estresse Oxidativo
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Ciclofilinas
Idioma:
En
Revista:
Journal of the Korean Society of Hypertension
Ano de publicação:
2011
Tipo de documento:
Article