Freeze-drying of silymarin-loaded solid lipid nanoparticles (SM-SLN) / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 110-112, 2005.
Article
em Zh
| WPRIM
| ID: wpr-276636
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate lyophilization of SM-SLN.</p><p><b>METHOD</b>The parameters of lyophilization process was optimized. In addition, the protective effect of various types and concentrations of cryoprotectants were tested by shape, colour and disparity.</p><p><b>RESULT</b>The mixture of 2% lactose and 2% glucose could better prevent nanoparticles from aggregating, the optimal lyophilization process was followed: precooled at -45 degrees C for 10 hr; primary drying at -25 degrees C for 5 hr; secondary drying at 10 degrees C for 3 hr; finally drying at 30 degrees C for 6 hr.</p><p><b>CONCLUSION</b>Changes in particle size distribution during lyophilization could be minimized by optimizing the parameters of the lyophilization process and adding supporting agent.</p>
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Índice:
WPRIM
Assunto principal:
Tamanho da Partícula
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Plantas Medicinais
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Silimarina
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Portadores de Fármacos
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Química
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Tecnologia Farmacêutica
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Silybum marianum
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Nanotecnologia
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Liofilização
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Glucose
Idioma:
Zh
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2005
Tipo de documento:
Article