Gene rearrangement studies in Hashimoto's thyroiditis and primary lymphoma of thyroid / 中华病理学杂志
Chinese Journal of Pathology
;
(12): 344-347, 2006.
Artigo
em Chinês
| WPRIM
| ID: wpr-277402
ABSTRACT
<p><b>OBJECTIVE</b>To study the immunoglobulin gene rearrangement patterns in Hashimoto's thyroiditis (HT) and primary thyroid lymphoma (PTL), and to analyze the relationship between the two diseases.</p><p><b>METHODS</b>Formalin-fixed and paraffin-embedded tissues of 11 cases of PTL and 38 cases of HT as well as their clinical data, were retrieved. The latter group was further subcategorized into classic HT and suspicious PTL. Gene rearrangement studies for immunoglobulin heavy chains and light chains were carried out by polymerase chain reaction (PCR) using VH, FR3A and FR3kappa primers.</p><p><b>RESULTS</b>There was an increasing trend in immunoglobulin gene rearrangement rate for classic HT (10.7%), suspicious PTL (40.0%) and PTL (72.7%) groups. In general, a female predilection was observed. This sex predilection however was less obvious in the PTL group. There was no relationship between serum antibody (both thyroglobulin and thyroid peroxidase) titers and gene rearrangement patterns.</p><p><b>CONCLUSIONS</b>HT and PTL show morphologic overlaps and may not be clearly distinguished on the basis of light microscopy alone. PCR-based immunoglobulin gene rearrangement study may be helpful in the detection of cases with early lymphomatous transformation of HT.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Tireoidite Autoimune
/
Neoplasias da Glândula Tireoide
/
Rearranjo Gênico
/
Caracteres Sexuais
/
Doença de Hashimoto
/
Identidade de Gênero
/
Genética
/
Linfoma
Limite:
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Pathology
Ano de publicação:
2006
Tipo de documento:
Artigo
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