Expression of fragile histidine triad (FHIT) protein and its significance in diagnosing classical Hodgkin lymphoma / 中华病理学杂志
Chinese Journal of Pathology
;
(12): 289-291, 2006.
Artigo
em Chinês
| WPRIM
| ID: wpr-277418
ABSTRACT
<p><b>OBJECTIVE</b>To study the expression of FHIT protein and its potential application in diagnosing classic Hodgkin lymphoma.</p><p><b>METHODS</b>Immunohistochemical study using EnVision method for FHIT tumor suppressor protein, hematopoietic stem cell markers CD133/AC133 and CD34, B-cell marker CD20, T-cell marker CD3 and oncoprotein c-erbB2 was performed on 33 cases of classic Hodgkin lymphoma.</p><p><b>RESULTS</b>Thirty-three of the Hodgkin lymphoma cases (90.9%) expressed FHIT protein. The antigen was mainly located in the cytoplasm, nucleus and membrane of classic Reed-Sternberg and Reed-Sternberg-like cells. Normal B and T lymphocytes, as well as their malignant counterparts, were negative for FHIT protein; whereas monocytes, histiocytes and dendritic cells were positive. All the cases studied were negative for CD133/AC133, CD34, CD3 and c-erbB-2. Two of the 33 cases showed positive staining for CD20 in some of the Reed-Sternberg cells.</p><p><b>CONCLUSION</b>The expression of FHIT protein can be used as a useful adjunct in diagnosing classic Hodgkin lymphoma.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Peptídeos
/
Doença de Hodgkin
/
Imuno-Histoquímica
/
Glicoproteínas
/
Biomarcadores Tumorais
/
Antígenos CD
/
Núcleo Celular
/
Sensibilidade e Especificidade
/
Células de Reed-Sternberg
/
Hidrolases Anidrido Ácido
Tipo de estudo:
Estudo diagnóstico
Limite:
Adolescente
/
Adulto
/
Idoso
/
Aged80
/
Criança
/
Criança, pré-escolar
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Pathology
Ano de publicação:
2006
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS