Expression and diagnostic application of C4.4A protein in squamous cell carcinoma and adenocarcinoma / 中华病理学杂志
Chinese Journal of Pathology
;
(12): 277-280, 2006.
Artigo
em Chinês
| WPRIM
| ID: wpr-277421
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the diagnostic utility of C4.4A gene expression in discriminating a squamous cell carcinoma (SCC) from an adenocarcinoma by immunohistochemistry.</p><p><b>METHODS</b>Immunohistochemical staining was performed to detect the expression of C4.4A protein in 157 cases of SCC and 177 cases of adenocarcinoma of various organs.</p><p><b>RESULTS</b>Overall, 141 of 157 cases of SCC strongly expressed C4.4A protein. In contrast, only 8 of 177 adenocarcinomas showed partial or scattered cell expression of C4.4A protein. The statistic difference between the two groups was highly significant (chi(2) = 244.93, P = 0.000), and also when the tumors were stratified according to the degree of differentiation (P = 0.000).</p><p><b>CONCLUSION</b>C4.4A protein expression may serve as a valuable tumor marker in discriminating a squamous cell carcinoma from an adenocarcinoma, and therefore, may greatly facilitate the differential diagnosis of an epithelial malignancy.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Neoplasias Gástricas
/
Neoplasias Esofágicas
/
Imuno-Histoquímica
/
Carcinoma de Células Escamosas
/
Neoplasias Colorretais
/
Adenocarcinoma
/
Biomarcadores Tumorais
/
Moléculas de Adesão Celular
/
Neoplasias do Colo do Útero
/
Diagnóstico
Tipo de estudo:
Estudo diagnóstico
Limite:
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Pathology
Ano de publicação:
2006
Tipo de documento:
Artigo
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