Insulino-mimetic effects of bis (alpha-furancarboxylato) oxovanadium (IV) in vitro / 药学学报
Acta Pharmaceutica Sinica
; (12): 318-322, 2008.
Article
em Zh
| WPRIM
| ID: wpr-277854
Biblioteca responsável:
WPRO
ABSTRACT
To study insulino-mimetic effects of bis(alpha-furancarboxylato) oxovanadium (IV) (BFOV), a orally active antidiabetic vanadyl complex, on glucose uptake and lipogenesis in isolated rat adipocytes were determined by using 2-deoxy-D-[3H]-glucose and D-[3H]-glucose, respectively. Lipolysis was assayed by free fatty acids (FFA) released from isolated rat adipocytes treated with epinephrine. The results showed that BFOV, similar to insulin, concentration-dependently significantly enhanced the uptake of 2-deoxy-D-[3H]-glucose and the transformation from D-[3H]-glucose to lipid in isolated rat adipocytes, with the EC50 values of (0.31 +/- 0.08) mmol L(-1) and (0.49 +/- 0.12) mmol L(-1), respectively. Moreover, BFOV markedly inhibited FFA release from isolated rat adipocytes treated with epinephrine, and the IC50 value was (0.30 +/- 0.20) mmol L(-1). BFOV had insulino-mimetic effects such as enhancing glucose uptake and lipogenesis, as well as inhibiting lipolysis.
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Índice:
WPRIM
Assunto principal:
Compostos Organometálicos
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Farmacologia
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Glicemia
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Ratos Sprague-Dawley
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Adipócitos
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Lipogênese
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Hipoglicemiantes
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Insulina
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Metabolismo
Limite:
Animals
Idioma:
Zh
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2008
Tipo de documento:
Article