Research Advances in the Mutation of TET2 Gene in Myeloid Maligancies / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
; (6): 583-588, 2016.
Article
em En
| WPRIM
| ID: wpr-277936
Biblioteca responsável:
WPRO
ABSTRACT
TET2 gene is a member of TET oncogene family. It has been reported as a tumor suppressor gene with important roles in myelopiesis. Recent studies have shown that TET2 protein takes part in demethylation by converting 5-methylcytosine (5-mc) into 5-hydroxymethylcytosine (5-hmc). Somatic TET2 inactivation leads to abnormal myelopiesis and myeloid malignancies. In this review,the structure and function of TET2 and the relationship between TET gene mutation and myeloid malignancies are summarized.
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Proteínas Proto-Oncogênicas
/
Neoplasias Hematológicas
/
5-Metilcitosina
/
Proteínas de Ligação a DNA
/
Genética
/
Metabolismo
/
Mutação
Limite:
Humans
Idioma:
En
Revista:
Acta Academiae Medicinae Sinicae
Ano de publicação:
2016
Tipo de documento:
Article