Research Advances in Pituitary Adenoma and DNA Methylation / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 475-479, 2016.
Artigo
em Inglês
| WPRIM
| ID: wpr-277953
ABSTRACT
DNA methylation is closely related to the genesis and development of pituitary adenoma. Studies have shown that high methylation in the promoter region of potassium voltage-gated chanel,shaker related subfamily,beta member 2,O-6-methylguanine-DNA methyltransferase,echinoderm microtubule associated protein like 2 ,ras homolog family member D ,homeobox B1 ,NNAT, and P16 inhibits the expression of these genes and regulates of the proliferation of pituitary adenoma. DNA methylation is also closely related to invasive pituitary adenoma. Therefore,further study on molecular mechanism of DNA methylation of pituitary adenoma will offer a new strategy for the diagnosis and treatment of pituitary adenoma.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Neoplasias Hipofisárias
/
Adenoma
/
Regulação Neoplásica da Expressão Gênica
/
Regiões Promotoras Genéticas
/
Metilação de DNA
/
Genética
Limite:
Humanos
Idioma:
Inglês
Revista:
Acta Academiae Medicinae Sinicae
Ano de publicação:
2016
Tipo de documento:
Artigo
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